Spyre Therapeutics Ownership | Who Owns Spyre Therapeutics?

Overview Forecast RevenueFinancials Chart

Spyre Therapeutics Ownership Summary

Spyre Therapeutics is owned by 7.08% institutional investors, 5.90% insiders, and 87.02% retail investors. Vanguard group is the largest institutional shareholder, holding 5.39% of SYRE shares. Fidelity Growth Compy Commingled Pl S is the top mutual fund, with 4.11% of its assets in Spyre Therapeutics shares.

SYRE Ownership Benchmark

Type	Name	% Inst	% Insiders	% Retail
Stock	Spyre Therapeutics	7.08%	5.90%	87.02%
Sector	Healthcare Stocks	35.64%	12.08%	52.28%
Industry	Biotech Stocks	35.26%	12.00%	52.74%

Institutional Shareholders

Top Institutional Shareholders by Total Shares

Holder	Shares	% Holding	Value
Vanguard group	4.04M	5.39%	$132.19M
Fmr	11.78M	3.40%	$594.23M
Blackrock funding, inc. /de	5.52M	1.60%	$278.49M
Boxer capital	696.48K	1.54%	$20.48M
Rtw investments, lp	4.17M	1.21%	$210.44M
Fairmount funds management	4.02M	1.16%	$202.67M
Perceptive advisors	3.78M	1.09%	$190.83M
Vr adviser	3.69M	1.06%	$185.89M
Driehaus capital management	2.79M	0.81%	$140.77M
State street	2.61M	0.75%	$131.50M

Top Institutional Shareholders by % of Total Assets

Holder	Shares	% Assets	Value
Fairmount funds management	4.02M	14.64%	$202.67M
Vr adviser	3.69M	6.94%	$185.89M
Commodore capital lp	1.91M	5.58%	$96.46M
Tang capital management	1.89M	4.85%	$95.44M
B group	100.00K	3.74%	$5.04M
Perceptive advisors	3.78M	3.73%	$190.83M
Affinity asset advisors	1.28M	3.33%	$64.52M
Caligan partners lp	878.13K	2.95%	$44.29M
Tcg crossover management	1.90M	2.74%	$95.87M
Rtw investments, lp	4.17M	2.09%	$210.44M

Top Buyers

Holder	Shares	% Assets	Change
Vanguard group	4.04M	0.00%	984.34K
Jpmorgan chase	979.30K	0.00%	916.35K
Caligan partners lp	878.13K	2.95%	878.13K
Perceptive advisors	3.78M	3.73%	714.00K
Paradigm biocapital advisors lp	1.96M	2.02%	490.00K

Top Sellers

Holder	Shares	% Assets	Change
Capital investors	1.75M	0.02%	-1.75M
Jefferies financial group	-	-	-1.39M
Deerfield management company, l.p. (series c)	-	-	-710.63K
Braidwell lp	932.82K	1.57%	-701.79K
Farallon capital management	-	-	-666.00K

New Positions

Holder	Shares	% Assets	Change	Value
Caligan partners lp	878.13K	2.95%	878.13K	$44.29M
Vanguard fiduciary trust	464.65K	0.01%	464.65K	$23.44M
Samlyn capital	396.66K	0.34%	396.66K	$20.01M
Boothbay fund management	193.03K	0.13%	193.03K	$9.74M
First trust advisors lp	178.39K	0.01%	178.39K	$9.00M

Sold Out

Holder	Change
National bank of canada /fi/	-1.00
Massmutual trust co fsb/adv	-3.00
Amundi	-5.00
Pacific capital wealth advisors	-8.00
True wealth design	-16.00

Institutional Ownership Trends

Date	Holdings	Change %	Shares	Change %	Ownership	Change %	Increased Position	Change %	Decreased Position	Change %
Mar 31, 2026	116	-25.64%	24,505,642	-69.74%	7	0.06%	75	-29.91%	28	3.70%
Dec 31, 2025	114	-17.39%	40,966,319	-36.29%	54	0.74%	79	19.70%	18	-59.09%
Sep 30, 2025	132	1.54%	61,991,182	-2.57%	102	0.93%	62	-25.30%	42	68.00%
Jun 30, 2025	129	-1.53%	63,612,503	9.51%	104	37.19%	81	10.96%	26	-23.53%
Mar 31, 2025	132	0.76%	62,108,053	3.71%	17	0.13%	73	-23.96%	34	78.95%

Top Mutual Funds Shareholders

Holder	Shares	% Holding	Change
Fidelity Growth Compy Commingled Pl S	3.57M	4.11%	179.24K
Fidelity Growth Company Fund	2.58M	2.97%	142.68K
Vanguard Total Stock Mkt Idx Inv	2.48M	2.86%	34.95K
American Funds SMALLCAP World A	2.41M	2.78%	-1.28M
iShares Russell 2000 ETF	1.92M	2.21%	11.42K
State Street® SPDR® S&P® Biotech ETF	1.32M	1.52%	-29.34K
Polar Capital Biotech S Inc	935.11K	1.08%	-51.15K
Vanguard Small Cap Index	896.64K	1.03%	885.05K
Vanguard Institutional Extnd Mkt Idx Tr	886.78K	1.02%	40.36K
Fidelity Advisor Biotechnology I	855.65K	0.99%	3.88K

Recent Insider Transactions

Date	Name	Role	Activity	Value
Jul 01, 2026	Burrows Scott L	Chief Financial Officer	Sell	$505.60K
Jul 01, 2026	Burrows Scott L	Chief Financial Officer	Sell	$152.44K
Jul 01, 2026	Sloan Sheldon	Chief Medical Officer	Sell	$162.02K
Jul 01, 2026	Sloan Sheldon	Chief Medical Officer	Sell	$568.88K
Jul 01, 2026	Turtle Cameron	Chief Executive Officer	Sell	$889.79K

Insider Transactions Trends

Date	Buy	Sell
2026 Q3	-	7
2026 Q2	-	34
2026 Q1	-	9
2025 Q4	-	4
2025 Q3	-	1

SYRE Ownership FAQ

Who Owns Spyre Therapeutics?

Spyre Therapeutics shareholders are primarily institutional investors at 7.08%, followed by 5.90% insiders and 87.02% retail investors. The average institutional ownership in Spyre Therapeutics's industry, Biotech Stocks , is 35.26%, which Spyre Therapeutics falls below.

Who owns the most shares of Spyre Therapeutics?

Spyre Therapeutics’s largest shareholders are Vanguard group (4.04M shares, 5.39%), Fmr (11.78M shares, 3.40%), and Blackrock funding, inc. /de (5.52M shares, 1.60%). Together, they hold 10.39% of Spyre Therapeutics’s total shares outstanding.

Does Blackrock own Spyre Therapeutics?

BlackRock is not among the top 10 institutional shareholders of Spyre Therapeutics.

Who is Spyre Therapeutics’s biggest shareholder by percentage of total assets invested?

Fairmount funds management is Spyre Therapeutics’s biggest shareholder by percentage of total assets invested, with 14.64% of its assets in 4.02M Spyre Therapeutics shares, valued at 202.67M$.

Who is the top mutual fund holder of Spyre Therapeutics shares?

Fidelity Growth Compy Commingled Pl S is the top mutual fund holder of Spyre Therapeutics shares, with 4.11% of its total shares outstanding invested in 3.57M Spyre Therapeutics shares.

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