Spyre Therapeutics Ownership | Who Owns Spyre Therapeutics?
Spyre Therapeutics Ownership Summary
Spyre Therapeutics is owned by 104.80% institutional investors, 8.71% insiders. Fmr is the largest institutional shareholder, holding 17.29% of SYRE shares.
SYRE Ownership Benchmark
| Type | Name | % Inst | % Insiders | % Retail |
|---|---|---|---|---|
| Stock | Spyre Therapeutics | 104.80% | 8.71% | -13.51% |
| Sector | Healthcare Stocks | 488.17% | 11.08% | -399.26% |
| Industry | Biotech Stocks | 306.59% | 11.10% | -217.69% |
Institutional Shareholders
Top Institutional Shareholders by Total Shares
| Holder | Shares | % Holding | Value |
|---|---|---|---|
| Fmr | 8.80M | 17.29% | $204.89M |
| Fairmount funds management | 4.02M | 6.62% | $60.15M |
| Blackrock funding, inc. /de | 4.01M | 6.60% | $59.99M |
| Rtw investments, lp | 3.62M | 5.97% | $54.22M |
| Vanguard group | 2.85M | 5.59% | $66.27M |
| Tang capital management | 3.20M | 5.27% | $47.90M |
| Vr adviser | 2.69M | 4.42% | $40.20M |
| Braidwell lp | 2.58M | 4.25% | $38.60M |
| Capital investors | 2.39M | 3.94% | $35.82M |
| Commodore capital lp | 1.99M | 3.91% | $46.28M |
Top Institutional Shareholders by % of Total Assets
| Holder | Shares | % Assets | Value |
|---|---|---|---|
| Fairmount funds management | 4.02M | 7.79% | $60.15M |
| Commodore capital lp | 1.99M | 3.39% | $46.28M |
| Vr adviser | 2.69M | 3.01% | $40.20M |
| Tang capital management | 3.20M | 2.42% | $47.90M |
| Braidwell lp | 2.58M | 1.32% | $38.60M |
| Affinity asset advisors | 606.68K | 1.24% | $9.08M |
| Paradigm biocapital advisors lp | 1.53M | 1.24% | $35.55M |
| Boxer capital | 696.48K | 1.01% | $20.48M |
| Perceptive advisors | 1.53M | 0.85% | $22.90M |
| Rtw investments, lp | 3.62M | 0.77% | $54.22M |
Top Buyers
| Holder | Shares | % Assets | Change |
|---|---|---|---|
| Fmr | 8.80M | 0.01% | 1.18M |
| Tang capital management | 3.20M | 2.42% | 1.15M |
| Baker bros. advisors lp | 626.70K | 0.09% | 626.70K |
| Goldman sachs group | 747.55K | 0.00% | 578.24K |
| Blackrock funding, inc. /de | 4.01M | 0.00% | 434.62K |
Top Sellers
| Holder | Shares | % Assets | Change |
|---|---|---|---|
| Perceptive advisors | 1.53M | 0.85% | -783.83K |
| Farallon capital management | - | - | -666.00K |
| Driehaus capital management | 2.09M | 0.25% | -631.72K |
| Avoro capital advisors | - | - | -598.60K |
| Logos global management lp | - | - | -500.00K |
New Positions
| Holder | Shares | % Assets | Change | Value |
|---|---|---|---|---|
| Baker bros. advisors lp | 626.70K | 0.09% | 626.70K | $9.38M |
| Victory capital management | 268.08K | 0.01% | 268.08K | $6.24M |
| Capitolis liquid global markets | 183.00K | 0.02% | 183.00K | $2.74M |
| Mercer global advisors inc /adv | 106.14K | 0.00% | 106.14K | $1.59M |
| Norges bank | 70.84K | 0.00% | 70.84K | $1.67M |
Sold Out
| Holder | Change |
|---|---|
| National bank of canada /fi/ | -1.00 |
| Amundi | -5.00 |
| Pacific capital wealth advisors | -8.00 |
| Us bancorp \de\ | -9.00 |
| Parallel advisors | -14.00 |
Institutional Ownership Trends
| Date | Holdings | Change % | Shares | Change % | Ownership | Change % | Increased Position | Change % | Decreased Position | Change % |
|---|---|---|---|---|---|---|---|---|---|---|
| Jun 30, 2025 | 129 | -1.53% | 63,612,503 | 9.51% | 104 | 37.19% | 81 | 10.96% | 26 | -23.53% |
| Mar 31, 2025 | 132 | 0.76% | 62,108,053 | 3.71% | 17 | 0.13% | 73 | -23.96% | 34 | 78.95% |
| Dec 31, 2024 | 120 | - | 50,788,525 | -1.15% | 99 | 0.78% | 86 | 19.44% | 18 | -25.00% |
| Sep 30, 2024 | 55 | -49.07% | 19,042,524 | -62.21% | 42 | 0.34% | 42 | -44.00% | 5 | -70.59% |
| Mar 31, 2024 | 102 | 82.14% | 31,642,952 | 12.97% | 86 | 0.27% | 74 | 68.18% | 15 | 200.00% |
Recent Insider Transactions
| Date | Name | Role | Activity | Value |
|---|---|---|---|---|
| Sep 02, 2025 | Burrows Scott L | Chief Financial Officer | Sell | $299.64K |
| Nov 06, 2024 | Albers Jeffrey W. | - | Sell | $246.31K |
| Oct 25, 2024 | Albers Jeffrey W. | - | Sell | $10.93K |
| Sep 03, 2024 | Burrows Scott L | Chief Financial Officer | Sell | $522.07K |
Insider Transactions Trends
| Date | Buy | Sell |
|---|---|---|
| 2025 Q3 | - | 1 |
| 2025 Q2 | - | - |
| 2025 Q1 | - | - |
| 2024 Q4 | - | 2 |
| 2024 Q3 | - | 1 |
SYRE Ownership FAQ
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