Spyre Therapeutics Ownership | Who Owns Spyre Therapeutics?
Spyre Therapeutics Ownership Summary
Spyre Therapeutics is owned by 27.86% institutional investors, 5.74% insiders, and 66.41% retail investors. Vanguard group is the largest institutional shareholder, holding 5.39% of SYRE shares. Fidelity Growth Compy Commingled Pl S is the top mutual fund, with 4.18% of its assets in Spyre Therapeutics shares.
SYRE Ownership Benchmark
| Type | Name | % Inst | % Insiders | % Retail |
|---|---|---|---|---|
| Stock | Spyre Therapeutics | 27.86% | 5.74% | 66.41% |
| Sector | Healthcare Stocks | 246.48% | 12.12% | -158.60% |
| Industry | Biotech Stocks | 384.82% | 11.76% | -296.58% |
Institutional Shareholders
Top Institutional Shareholders by Total Shares
| Holder | Shares | % Holding | Value |
|---|---|---|---|
| Vanguard group | 4.04M | 5.39% | $132.19M |
| Fmr | 13.03M | 3.76% | $1.16B |
| Blackrock funding, inc. /de | 6.51M | 1.88% | $577.66M |
| Boxer capital | 696.48K | 1.54% | $20.48M |
| Perceptive advisors | 4.32M | 1.25% | $383.48M |
| Rtw investments, lp | 4.25M | 1.23% | $377.49M |
| Paradigm biocapital advisors lp | 3.84M | 1.11% | $340.98M |
| Vanguard capital management | 3.45M | 1.00% | $306.17M |
| State street | 3.06M | 0.88% | $271.44M |
| Vr adviser | 2.99M | 0.86% | $265.05M |
Top Institutional Shareholders by % of Total Assets
| Holder | Shares | % Assets | Value |
|---|---|---|---|
| Vr adviser | 2.99M | 8.04% | $265.05M |
| Tang capital management | 1.89M | 7.63% | $167.99M |
| Monashee investment management | 50.00K | 7.45% | $4.44M |
| Paradigm biocapital advisors lp | 3.84M | 6.38% | $340.98M |
| Perceptive advisors | 4.32M | 5.76% | $383.48M |
| Affinity asset advisors | 1.28M | 5.13% | $113.56M |
| Commodore capital lp | 846.79K | 4.48% | $75.18M |
| Tcg crossover management | 1.90M | 4.06% | $168.73M |
| Rtw investments, lp | 4.25M | 3.22% | $377.49M |
| B group | 70.00K | 2.92% | $6.21M |
Top Buyers
| Holder | Shares | % Assets | Change |
|---|---|---|---|
| Paradigm biocapital advisors lp | 3.84M | 6.38% | 1.88M |
| Adage capital partners gp | 1.72M | 0.21% | 1.72M |
| Capital world investors | 2.32M | 0.02% | 1.65M |
| Price t rowe associates inc /md/ | 2.96M | 0.03% | 1.36M |
| Fmr | 13.03M | 0.05% | 1.25M |
Top Sellers
| Holder | Shares | % Assets | Change |
|---|---|---|---|
| Fairmount funds management | - | - | -4.02M |
| Ra capital management | - | - | -1.62M |
| Jefferies financial group | - | - | -1.39M |
| Commodore capital lp | 846.79K | 4.48% | -1.07M |
| Baker bros. advisors lp | - | - | -1.00M |
New Positions
| Holder | Shares | % Assets | Change | Value |
|---|---|---|---|---|
| Adage capital partners gp | 1.72M | 0.21% | 1.72M | $152.91M |
| Holocene advisors, lp | 1.02M | 0.20% | 1.02M | $90.13M |
| Sixth street partners management company | 652.96K | 0.01% | 652.96K | $57.97M |
| Integral health asset management | 325.00K | 1.14% | 325.00K | $28.85M |
| Jennison associates | 303.18K | 0.02% | 303.18K | $26.92M |
Sold Out
| Holder | Change |
|---|---|
| Twin peaks wealth advisors | -3.00 |
| Massmutual trust co fsb/adv | -3.00 |
| Pacific capital wealth advisors | -8.00 |
| Ares financial consulting | -11.00 |
| Mai capital management | -13.00 |
Institutional Ownership Trends
| Date | Holdings | Change % | Shares | Change % | Ownership | Change % | Increased Position | Change % | Decreased Position | Change % |
|---|---|---|---|---|---|---|---|---|---|---|
| Jun 30, 2026 | 271 | 35.50% | 96,392,328 | 16.63% | 27 | 4.88% | 193 | 56.91% | 56 | 12.00% |
| Mar 31, 2026 | 116 | -25.64% | 24,505,642 | -69.74% | 7 | 0.06% | 75 | -29.91% | 28 | 3.70% |
| Dec 31, 2025 | 114 | -17.39% | 40,966,319 | -36.29% | 54 | 0.74% | 79 | 19.70% | 18 | -59.09% |
| Sep 30, 2025 | 132 | 1.54% | 61,991,182 | -2.57% | 102 | 0.93% | 62 | -25.30% | 42 | 68.00% |
| Jun 30, 2025 | 129 | -1.53% | 63,612,503 | 9.51% | 104 | 37.19% | 81 | 10.96% | 26 | -23.53% |
Top Mutual Funds Shareholders
| Holder | Shares | % Holding | Change |
|---|---|---|---|
| Fidelity Growth Compy Commingled Pl S | 3.68M | 4.18% | 115.91K |
| Fidelity Growth Company Fund | 2.76M | 3.09% | 93.42K |
| Vanguard Total Stock Mkt Idx Inv | 2.48M | 2.86% | 34.95K |
| Vanguard Morn Total Stk Mkt Idx Investor | 2.48M | 2.86% | 34.95K |
| Vanguard MStar Total Stk Mkt Idx Invest | 2.49M | 2.82% | -2.99K |
| American Funds SMALLCAP World A | 2.25M | 2.52% | -315.51K |
| iShares Russell 2000 ETF | 1.98M | 2.25% | -16.26K |
| Vanguard Small Cap Index | 1.88M | 2.11% | 957.41K |
| State Street® SPDR® S&P® Biotech ETF | 1.71M | 1.94% | -32.55K |
| Vanguard MStar Small Cap Value Index | 1.23M | 1.37% | 656.01K |
Recent Insider Transactions
| Date | Name | Role | Activity | Value |
|---|---|---|---|---|
| Oct 01, 2026 | King-Jones Heidy | See Remarks | Sell | $660.28K |
| Oct 01, 2026 | King-Jones Heidy | See Remarks | Sell | $194.67K |
| Oct 01, 2026 | King-Jones Heidy | See Remarks | Sell | $35.70K |
| Oct 01, 2026 | King-Jones Heidy | See Remarks | Sell | $1.50M |
| Oct 01, 2026 | King-Jones Heidy | See Remarks | Sell | $243.00K |
Insider Transactions Trends
| Date | Buy | Sell |
|---|---|---|
| 2026 Q4 | - | 16 |
| 2026 Q3 | - | 33 |
| 2026 Q2 | - | 34 |
| 2026 Q1 | - | 9 |
| 2025 Q4 | - | 4 |
SYRE Ownership FAQ
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