Spyre Therapeutics Ownership | Who Owns Spyre Therapeutics?
Spyre Therapeutics Ownership Summary
Spyre Therapeutics is owned by 27.86% institutional investors, 5.74% insiders, and 66.41% retail investors. Vanguard group is the largest institutional shareholder, holding 5.39% of SYRE shares. Fidelity Growth Compy Commingled Pl S is the top mutual fund, with 4.18% of its assets in Spyre Therapeutics shares.
SYRE Ownership Benchmark
| Type | Name | % Inst | % Insiders | % Retail |
|---|---|---|---|---|
| Stock | Spyre Therapeutics | 27.86% | 5.74% | 66.41% |
| Sector | Healthcare Stocks | 244.59% | 12.11% | -156.70% |
| Industry | Biotech Stocks | 379.61% | 11.70% | -291.31% |
Institutional Shareholders
Top Institutional Shareholders by Total Shares
| Holder | Shares | % Holding | Value |
|---|---|---|---|
| Vanguard group | 4.04M | 5.39% | $132.19M |
| Fmr | 13.03M | 3.76% | $1.16B |
| Blackrock funding, inc. /de | 6.51M | 1.88% | $577.66M |
| Boxer capital | 696.48K | 1.54% | $20.48M |
| Perceptive advisors | 4.32M | 1.25% | $383.48M |
| Rtw investments, lp | 4.25M | 1.23% | $377.49M |
| Paradigm biocapital advisors lp | 3.84M | 1.11% | $340.98M |
| Vanguard capital management | 3.45M | 1.00% | $306.17M |
| State street | 3.06M | 0.88% | $271.44M |
| Vr adviser | 2.99M | 0.86% | $265.05M |
Top Institutional Shareholders by % of Total Assets
| Holder | Shares | % Assets | Value |
|---|---|---|---|
| Vr adviser | 2.99M | 8.04% | $265.05M |
| Tang capital management | 1.89M | 7.63% | $167.99M |
| Monashee investment management | 50.00K | 7.45% | $4.44M |
| Paradigm biocapital advisors lp | 3.84M | 6.38% | $340.98M |
| Perceptive advisors | 4.32M | 5.76% | $383.48M |
| Affinity asset advisors | 1.28M | 5.13% | $113.56M |
| Commodore capital lp | 846.79K | 4.48% | $75.18M |
| Tcg crossover management | 1.90M | 4.06% | $168.73M |
| Rtw investments, lp | 4.25M | 3.22% | $377.49M |
| B group | 70.00K | 2.92% | $6.21M |
Top Buyers
| Holder | Shares | % Assets | Change |
|---|---|---|---|
| Paradigm biocapital advisors lp | 3.84M | 6.38% | 1.88M |
| Adage capital partners gp | 1.72M | 0.21% | 1.72M |
| Capital world investors | 2.32M | 0.02% | 1.65M |
| Price t rowe associates inc /md/ | 2.96M | 0.03% | 1.36M |
| Fmr | 13.03M | 0.05% | 1.25M |
Top Sellers
| Holder | Shares | % Assets | Change |
|---|---|---|---|
| Fairmount funds management | - | - | -4.02M |
| Ra capital management | - | - | -1.62M |
| Jefferies financial group | - | - | -1.39M |
| Commodore capital lp | 846.79K | 4.48% | -1.07M |
| Baker bros. advisors lp | - | - | -1.00M |
New Positions
| Holder | Shares | % Assets | Change | Value |
|---|---|---|---|---|
| Adage capital partners gp | 1.72M | 0.21% | 1.72M | $152.91M |
| Holocene advisors, lp | 1.02M | 0.20% | 1.02M | $90.13M |
| Sixth street partners management company | 652.96K | 0.01% | 652.96K | $57.97M |
| Integral health asset management | 325.00K | 1.14% | 325.00K | $28.85M |
| Jennison associates | 303.18K | 0.02% | 303.18K | $26.92M |
Sold Out
| Holder | Change |
|---|---|
| Twin peaks wealth advisors | -3.00 |
| Massmutual trust co fsb/adv | -3.00 |
| Pacific capital wealth advisors | -8.00 |
| Mai capital management | -13.00 |
| True wealth design | -16.00 |
Institutional Ownership Trends
| Date | Holdings | Change % | Shares | Change % | Ownership | Change % | Increased Position | Change % | Decreased Position | Change % |
|---|---|---|---|---|---|---|---|---|---|---|
| Jun 30, 2026 | 271 | 35.50% | 96,392,328 | 16.63% | 27 | 4.88% | 193 | 56.91% | 56 | 12.00% |
| Mar 31, 2026 | 116 | -25.64% | 24,505,642 | -69.74% | 7 | 0.06% | 75 | -29.91% | 28 | 3.70% |
| Dec 31, 2025 | 114 | -17.39% | 40,966,319 | -36.29% | 54 | 0.74% | 79 | 19.70% | 18 | -59.09% |
| Sep 30, 2025 | 132 | 1.54% | 61,991,182 | -2.57% | 102 | 0.93% | 62 | -25.30% | 42 | 68.00% |
| Jun 30, 2025 | 129 | -1.53% | 63,612,503 | 9.51% | 104 | 37.19% | 81 | 10.96% | 26 | -23.53% |
Top Mutual Funds Shareholders
| Holder | Shares | % Holding | Change |
|---|---|---|---|
| Fidelity Growth Compy Commingled Pl S | 3.68M | 4.18% | 115.91K |
| Fidelity Growth Company Fund | 2.66M | 3.06% | 84.41K |
| American Funds SMALLCAP World A | 2.56M | 2.95% | 150.57K |
| Vanguard Morn Total Stk Mkt Idx Investor | 2.48M | 2.86% | 34.95K |
| Vanguard Total Stock Mkt Idx Inv | 2.48M | 2.86% | 34.95K |
| Vanguard MStar Total Stk Mkt Idx Invest | 2.49M | 2.82% | 7.81K |
| iShares Russell 2000 ETF | 1.89M | 2.14% | -33.50K |
| State Street® SPDR® S&P® Biotech ETF | 1.30M | 1.48% | 2.99K |
| Polar Capital Biotech S Inc | 935.11K | 1.08% | - |
| Vanguard Small Cap Index | 898.64K | 1.02% | 2.01K |
Recent Insider Transactions
| Date | Name | Role | Activity | Value |
|---|---|---|---|---|
| Sep 02, 2026 | King-Jones Heidy | See Remarks | Sell | $36.00K |
| Sep 01, 2026 | King-Jones Heidy | See Remarks | Sell | $418.61K |
| Sep 01, 2026 | King-Jones Heidy | See Remarks | Sell | $1.44M |
| Sep 01, 2026 | King-Jones Heidy | See Remarks | Sell | $547.18K |
| Sep 01, 2026 | King-Jones Heidy | See Remarks | Sell | $35.75K |
Insider Transactions Trends
| Date | Buy | Sell |
|---|---|---|
| 2026 Q3 | - | 32 |
| 2026 Q2 | - | 34 |
| 2026 Q1 | - | 9 |
| 2025 Q4 | - | 4 |
| 2025 Q3 | - | 1 |
SYRE Ownership FAQ
Try Tickergate Pro Free
Customize Everything. 100% Flexibility. Fast and Easy to Use (No code or Excel Needed)
Customize your own personal stocks lists, views and charts
Choose from hundreds of fields, up to 15 years of history
Conduct deep comparison analysis
Discover trending investment themes
Find your next best investment
Research stocks using tools