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Upstream Bio Ownership | Who Owns Upstream Bio?

OverviewRevenueFinancialsChart

Upstream Bio Ownership Summary

Upstream Bio is owned by 78.75% institutional investors, 14.77% insiders, and 6.48% retail investors. Fmr is the largest institutional shareholder, holding 15.04% of UPB shares.

UPB Ownership Benchmark

TypeName% Inst% Insiders% Retail
StockUpstream Bio78.75%14.77%6.48%
SectorHealthcare Stocks 42.50%10.81%46.69%
IndustryBiotech Stocks 45.24%10.75%44.01%

Institutional Shareholders

Top Institutional Shareholders by Total Shares

HolderShares% HoldingValue
Fmr8.09M15.04%$152.11M
Orbimed advisors5.69M10.59%$107.10M
Decheng capital3.29M6.11%$61.80M
Blackrock funding, inc. /de2.60M4.84%$48.98M
Enavate sciences gp2.46M4.57%$46.27M
Vanguard group2.44M4.54%$45.94M
Bain capital life sciences investors2.44M4.54%$45.89M
Tcg crossover management2.12M3.94%$39.82M
Altshuler shaham1.42M2.63%$26.65M
Omega fund management1.36M2.52%$25.51M

Top Institutional Shareholders by % of Total Assets

HolderShares% AssetsValue
Enavate sciences gp2.46M14.13%$46.27M
Omega fund management1.36M11.47%$25.51M
Decheng capital3.29M10.78%$61.80M
Bain capital life sciences investors2.44M3.05%$45.89M
Orbimed advisors5.69M2.52%$107.10M
Samsara biocapital962.15K2.36%$18.10M
Great point partners300.00K2.33%$5.64M
Tcg crossover management2.12M1.96%$39.82M
Parkman healthcare partners843.50K1.66%$15.87M
Vr adviser1.17M1.24%$21.99M

Top Buyers

HolderShares% AssetsChange
State street1.11M0.00%633.21K
Marshall wace, llp868.00K0.02%577.47K
Integral health asset management575.00K0.73%575.00K
Blackrock funding, inc. /de2.60M0.00%507.20K
Vanguard group2.44M0.00%271.72K

Top Sellers

HolderShares% AssetsChange
Altshuler shaham1.42M0.44%-1.98M
Deep track capital, lp---1.44M
Vr adviser1.17M1.24%-1.13M
Tcg crossover management2.12M1.96%-684.66K
Omega fund management1.36M11.47%-680.00K

New Positions

HolderShares% AssetsChangeValue
Integral health asset management575.00K0.73%575.00K$10.82M
Ikarian capital161.11K0.31%161.11K$3.03M
Summittx capital112.40K0.09%112.40K$2.11M
Boothbay fund management61.30K0.02%61.30K$1.15M
Exome asset management51.96K0.59%51.96K$977.37K

Sold Out

HolderChange
Principal securities-12.00
True wealth design-31.00
Advisor group-42.00
Physician wealth advisors-69.00
Strs ohio-1.80K

Institutional Ownership Trends

DateHoldingsChange %SharesChange %OwnershipChange %Increased PositionChange %Decreased PositionChange %
Sep 30, 20259724.36%42,344,528-12.14%780.98%6321.15%1958.33%
Jun 30, 2025826.49%48,353,6776.86%891.26%55-28.57%13-
Mar 31, 202577-45,306,251-84-77---

Insider Transactions Trends

DateBuySell
2025 Q2--

UPB Ownership FAQ

Who Owns Upstream Bio?

Upstream Bio shareholders are primarily institutional investors at 78.75%, followed by 14.77% insiders and 6.48% retail investors. The average institutional ownership in Upstream Bio's industry, Biotech Stocks , is 45.24%, which Upstream Bio exceeds.

Who owns the most shares of Upstream Bio?

Upstream Bio’s largest shareholders are Fmr (8.09M shares, 15.04%), Orbimed advisors (5.69M shares, 10.59%), and Decheng capital (3.29M shares, 6.11%). Together, they hold 31.74% of Upstream Bio’s total shares outstanding.

Does Blackrock own Upstream Bio?

BlackRock is not among the top 10 institutional shareholders of Upstream Bio.

Who is Upstream Bio’s biggest shareholder by percentage of total assets invested?

Enavate sciences gp is Upstream Bio’s biggest shareholder by percentage of total assets invested, with 14.13% of its assets in 2.46M Upstream Bio shares, valued at 46.27M$.

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