Upstream Bio Ownership | Who Owns Upstream Bio?

Upstream Bio Ownership Summary

Upstream Bio is owned by 89.93% institutional investors, 19.81% insiders. Orbimed advisors is the largest institutional shareholder, holding 10.59% of UPB shares.

UPB Ownership Benchmark

Type	Name	% Inst	% Insiders	% Retail
Stock	Upstream Bio	89.93%	19.81%	-9.74%
Sector	Healthcare Stocks	486.50%	11.08%	-397.59%
Industry	Biotech Stocks	304.14%	11.08%	-215.23%

Institutional Shareholders

Top Institutional Shareholders by Total Shares

Holder	Shares	% Holding	Value
Orbimed advisors	5.69M	10.59%	$62.52M
Altshuler shaham	3.39M	6.31%	$37.27M
Decheng capital	3.29M	6.11%	$36.07M
Tcg crossover management	2.80M	5.21%	$30.76M
Bain capital life sciences investors	2.44M	4.54%	$26.79M
Vr adviser	2.30M	4.27%	$25.20M
Blackrock funding, inc. /de	2.10M	3.90%	$23.02M
Omega fund management	2.04M	3.79%	$22.36M
Samsara biocapital	1.44M	2.68%	$15.85M
Deep track capital, lp	1.44M	2.68%	$15.84M

Top Institutional Shareholders by % of Total Assets

Holder	Shares	% Assets	Value
Omega fund management	2.04M	14.48%	$22.36M
Decheng capital	3.29M	9.11%	$36.07M
Tcg crossover management	2.80M	3.51%	$30.76M
Bain capital life sciences investors	2.44M	3.35%	$26.79M
Samsara biocapital	1.44M	3.24%	$15.85M
Great point partners	300.00K	2.14%	$3.29M
Vr adviser	2.30M	1.89%	$25.20M
Orbimed advisors	5.69M	1.57%	$62.52M
Altshuler shaham	3.39M	1.18%	$37.27M
Parkman healthcare partners	715.50K	0.90%	$7.86M

Top Buyers

Holder	Shares	% Assets	Change
Blackrock funding, inc. /de	2.10M	0.00%	910.74K
Parkman healthcare partners	715.50K	0.90%	481.94K
Altshuler shaham	3.39M	1.18%	159.15K
Bain capital life sciences investors	2.44M	3.35%	144.22K
Verition fund management	33.51K	0.00%	33.51K

Top Sellers

Holder	Shares	% Assets	Change
Deep track capital, lp	1.44M	0.51%	-856.80K
Samsara biocapital	1.44M	3.24%	-623.91K
Two sigma investments, lp	-	-	-21.79K
Adar1 capital management	-	-	-15.00K
Marshall wace, llp	290.53K	0.00%	-14.44K

New Positions

Holder	Shares	% Assets	Change	Value
American century companies	22.36K	0.00%	22.36K	$245.53K
Virtus investment advisers	8.13K	0.03%	8.13K	$89.31K
Clearstead advisors	163.00	-	163.00	$1.79K

Sold Out

Holder	Change
Principal securities	-12.00
Physician wealth advisors	-69.00
Corebridge financial	-8.53K
Walleye capital	-10.00K
Xtx topco	-12.73K

Institutional Ownership Trends

Date	Holdings	Change %	Shares	Change %	Ownership	Change %	Increased Position	Change %	Decreased Position	Change %
Jun 30, 2025	82	6.49%	48,353,677	6.86%	89	1.26%	55	-28.57%	13	-
Mar 31, 2025	77	-	45,306,251	-	84	-	77	-	-	-

Insider Transactions Trends

Date	Buy	Sell
2025 Q2	-	-

UPB Ownership FAQ

Who Owns Upstream Bio?

Upstream Bio shareholders are primarily institutional investors at 89.93%, followed by 19.81% insiders and -9.74% retail investors. The average institutional ownership in Upstream Bio's industry, Biotech Stocks , is 304.14%, which Upstream Bio falls below.

Who owns the most shares of Upstream Bio?

Upstream Bio’s largest shareholders are Orbimed advisors (5.69M shares, 10.59%), Altshuler shaham (3.39M shares, 6.31%), and Decheng capital (3.29M shares, 6.11%). Together, they hold 23.01% of Upstream Bio’s total shares outstanding.

Does Blackrock own Upstream Bio?

BlackRock is not among the top 10 institutional shareholders of Upstream Bio.

Who is Upstream Bio’s biggest shareholder by percentage of total assets invested?

Omega fund management is Upstream Bio’s biggest shareholder by percentage of total assets invested, with 14.48% of its assets in 2.04M Upstream Bio shares, valued at 22.36M$.

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