Spero Therapeutics Ownership | Who Owns Spero Therapeutics?

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Spero Therapeutics Ownership Summary

Spero Therapeutics is owned by 4.38% institutional investors, 23.34% insiders, and 72.28% retail investors. Gsk is the largest institutional shareholder, holding 16.33% of SPRO shares. Vanguard Total Stock Mkt Idx Inv is the top mutual fund, with 2.20% of its assets in Spero Therapeutics shares.

SPRO Ownership Benchmark

Type	Name	% Inst	% Insiders	% Retail
Stock	Spero Therapeutics	4.38%	23.34%	72.28%
Sector	Healthcare Stocks	232.01%	10.74%	-142.75%
Industry	Biotech Stocks	381.47%	10.55%	-292.02%

Institutional Shareholders

Top Institutional Shareholders by Total Shares

Holder	Shares	% Holding	Value
Gsk	9.19M	16.33%	$21.41M
Pfizer	2.36M	4.20%	$5.50M
Vanguard group	2.08M	3.70%	$4.85M
Anson funds management lp	1.60M	2.86%	$3.01M
Renaissance	1.28M	2.27%	$2.98M
Alphabet	889.98K	1.59%	$1.67M
Geode capital management	529.20K	0.94%	$1.23M
Blackrock	483.40K	0.90%	$628.42K
Blackrock funding, inc. /de	433.62K	0.77%	$1.01M
Awm investment company	333.40K	0.62%	$433.42K

Top Institutional Shareholders by % of Total Assets

Holder	Shares	% Assets	Value
Gsk	9.19M	2.68%	$21.41M
Pfizer	2.36M	2.33%	$5.50M
Anson funds management lp	1.60M	0.27%	$3.01M
Intrepid family office	110.00K	0.17%	$206.80K
Alphabet	889.98K	0.07%	$1.67M
Awm investment company	333.40K	0.06%	$433.42K
Eam investors	218.08K	0.06%	$508.14K
Rangeley capital	30.00K	0.05%	$56.40K
Ionic capital management	208.72K	0.04%	$392.40K
Gsa capital partners llp	178.93K	0.04%	$417.00K

Top Buyers

Holder	Shares	% Assets	Change
Gsk	9.19M	2.68%	9.19M
Sei investments	132.01K	0.00%	132.01K
Jane street group	158.34K	0.00%	115.36K
Intrepid family office	110.00K	0.17%	110.00K
Vanguard group	2.08M	0.00%	93.61K

Top Sellers

Holder	Shares	% Assets	Change
Murchinson	-	-	-873.91K
Schonfeld strategic advisors	-	-	-510.83K
Novo	-	-	-468.90K
Monimus capital management, lp	-	-	-310.91K
Atlas venture life science advisors	-	-	-305.25K

New Positions

Holder	Shares	% Assets	Change	Value
Gsk	9.19M	2.68%	9.19M	$21.41M
Sei investments	132.01K	0.00%	132.01K	$307.58K
Intrepid family office	110.00K	0.17%	110.00K	$206.80K
Shay capital	63.67K	0.01%	63.67K	$119.69K
Two sigma investments, lp	49.40K	0.00%	49.40K	$92.87K

Sold Out

Holder	Change
Qube research	-1.00
Federation des caisses desjardins du quebec	-30.00
Northwestern mutual wealth management	-50.00
Pfs partners	-50.00
Corecap advisors	-50.00

Institutional Ownership Trends

Date	Holdings	Change %	Shares	Change %	Ownership	Change %	Increased Position	Change %	Decreased Position	Change %
Dec 31, 2025	10	-79.59%	2,465,493	-78.20%	4	1.07%	4	-85.19%	2	-71.43%
Sep 30, 2025	11	-74.42%	3,157,628	-71.20%	5	1.47%	3	-86.96%	1	-88.89%
Jun 30, 2025	45	9.76%	11,078,414	-26.67%	19	2.66%	24	118.18%	9	-10.00%
Mar 31, 2025	4	-92.31%	2,111,095	-86.54%	3	0.47%	-	-100.00%	-	-100.00%
Dec 31, 2024	52	10.64%	15,679,985	27.34%	28	5.60%	26	160.00%	9	-25.00%

Top Mutual Funds Shareholders

Holder	Shares	% Holding	Change
Vanguard Total Stock Mkt Idx Inv	1.24M	2.20%	-
Vanguard US Total Market Shares ETF	1.17M	2.09%	-
Vanguard Institutional Extnd Mkt Idx Tr	516.11K	0.92%	-
IMC US Ultra Micro Cap	264.02K	0.47%	-
Fidelity Extended Market Index	246.98K	0.44%	-1.00
Pleiades Small Cap Equity A	132.01K	0.23%	-38.96K
Blackrock Extended Mkt Fund CF	126.66K	0.22%	126.66K
Extended Equity Market Fund K	108.64K	0.19%	71.00
Fidelity Total Market Index	107.80K	0.19%	-
iShares Micro-Cap ETF	87.05K	0.16%	-

Recent Insider Transactions

Date	Name	Role	Activity	Value
Feb 06, 2026	Rajavelu Esther	See Remarks	Sell	$87.56K
Feb 06, 2026	Rajavelu Esther	See Remarks	Sell	$119.93K
Feb 06, 2026	Keutzer Timothy	Chief Operating Officer	Sell	$44.02K
Feb 03, 2026	Keutzer Timothy	Chief Operating Officer	Sell	$51.84K
Feb 04, 2026	Keutzer Timothy	Chief Operating Officer	Sell	$7.78K

Insider Transactions Trends

Date	Buy	Sell
2026 Q1	-	4
2025 Q4	-	1
2025 Q3	-	2
2025 Q2	-	-
2025 Q1	-	9

SPRO Ownership FAQ

Who Owns Spero Therapeutics?

Spero Therapeutics shareholders are primarily institutional investors at 4.38%, followed by 23.34% insiders and 72.28% retail investors. The average institutional ownership in Spero Therapeutics's industry, Biotech Stocks , is 381.47%, which Spero Therapeutics falls below.

Who owns the most shares of Spero Therapeutics?

Spero Therapeutics’s largest shareholders are Gsk (9.19M shares, 16.33%), Pfizer (2.36M shares, 4.20%), and Vanguard group (2.08M shares, 3.70%). Together, they hold 24.23% of Spero Therapeutics’s total shares outstanding.

Does Blackrock own Spero Therapeutics?

Yes, BlackRock owns 0.90% of Spero Therapeutics, totaling 483.4K shares as of Jun 2024. This represents 0% of BlackRock's total assets, with a market value of 628.42K$. In the last quarter, BlackRock increased its holdings by 6.51K shares, a 1.36% change.

Who is Spero Therapeutics’s biggest shareholder by percentage of total assets invested?

Gsk is Spero Therapeutics’s biggest shareholder by percentage of total assets invested, with 2.68% of its assets in 9.19M Spero Therapeutics shares, valued at 21.41M$.

Who is the top mutual fund holder of Spero Therapeutics shares?

Vanguard Total Stock Mkt Idx Inv is the top mutual fund holder of Spero Therapeutics shares, with 2.20% of its total shares outstanding invested in 1.24M Spero Therapeutics shares.

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