Spero Therapeutics (SPRO) Revenue & Revenue Breakdown


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Spero Therapeutics Revenue Highlights


Latest Revenue (Y)

$66.80M

Latest Revenue (Q)

$258.00K

Main Segment (Y)

Collaboration Revenue Related Party

Spero Therapeutics Revenue by Period


Spero Therapeutics Revenue by Year

DateRevenueChange
2025-12-31$66.80M39.24%
2024-12-31$47.98M-53.77%
2023-12-31$103.78M113.63%
2022-12-31$48.58M1482.38%
2021-12-31$3.07M-67.10%
2020-12-31$9.33M-48.59%
2019-12-31$18.15M357.56%
2018-12-31$3.97M100.40%
2017-12-31$1.98M490.75%
2016-12-31$335.00K100.00%
2015-12-31--

Spero Therapeutics generated $66.80M in revenue during NA 2025, up 39.24% compared to the previous quarter, and up 715.99% compared to the same period a year ago.

Spero Therapeutics Revenue by Quarter

DateRevenueChange
2026-03-31$258.00K-99.35%
2025-12-31$39.66M1201.12%
2025-09-30$3.05M-74.17%
2025-06-30$11.80M100.92%
2025-03-31$5.87M-60.95%
2024-12-31$15.04M11.69%
2024-09-30$13.47M32.09%
2024-06-30$10.20M142.55%
2024-03-31$4.20M-94.28%
2023-12-31$73.52M188.63%
2023-09-30$25.47M837.89%
2023-06-30$2.72M31.27%
2023-03-31$2.07M-95.54%
2022-12-31$46.35M4184.10%
2022-09-30$1.08M20.76%
2022-06-30$896.00K262.75%
2022-03-31$247.00K-91.00%
2021-12-31$2.74M287.57%
2021-09-30$708.00K-66.38%
2021-06-30$2.11M-71.15%
2021-03-31$7.30M282.80%
2020-12-31$1.91M-52.27%
2020-09-30$4.00M131.33%
2020-06-30$1.73M1.53%
2020-03-31$1.70M-53.14%
2019-12-31$3.63M2010.47%
2019-09-30$172.00K-92.02%
2019-06-30$2.16M-43.37%
2019-03-31$3.81M125.00%
2018-12-31$1.69M157.14%
2018-09-30$658.00K42.12%
2018-06-30$463.00K-59.84%
2018-03-31$1.15M16.11%
2017-12-31$993.00K66.33%
2017-09-30$597.00K139.76%
2017-06-30$249.00K77.86%
2017-03-31$140.00K-58.21%
2016-12-31$335.00K100.00%
2016-09-30--

Spero Therapeutics generated $258.00K in revenue during Q1 2026, up -99.35% compared to the previous quarter, and up 1.71% compared to the same period a year ago.

Spero Therapeutics Revenue Breakdown


Spero Therapeutics Revenue Breakdown by Product

Annual Revenue by Product

Product/ServiceDec 25Dec 24
Collaboration Revenue Related Party$47.03M$27.02M
Grant Revenue$7.18M$20.58M
Collaboration Revenue$12.59M$371.00K

Spero Therapeutics's latest annual revenue breakdown by segment (product or service), as of Dec 25: Collaboration Revenue Related Party (70.41%), Collaboration Revenue (18.84%), and Grant Revenue (10.75%).

Quarterly Revenue by Product

Product/ServiceMar 26Dec 25Sep 25Jun 25Mar 25
Collaboration Revenue Related Party$258.00K$27.08M$3.05M$11.80M$5.10M
Grant Revenue-$1.64M$2.39M$2.39M$763.00K
Collaboration Revenue-$12.57M$12.00K--

Spero Therapeutics's latest quarterly revenue breakdown by segment (product or service), as of Mar 26: Collaboration Revenue Related Party (100.00%).

Spero Therapeutics Peer Comparison by Revenue


TickerCompanyLast Year RevenueLast Quarter Revenue
SPROSpero Therapeutics$66.80M$258.00K
SEERSeer$16.58M$2.79M
VTGNVistaGen Therapeutics$1.06M$303.00K
MCRBSeres Therapeutics$789.00K$358.00K
ACTUActuate Therapeutics--
IRDOpus Genetics--
CRBPCorbus Pharmaceuticals--
INOInovio Pharmaceuticals--
CGTXCognition Therapeutics--
ABOSAcumen Pharmaceuticals--
HURATuHURA Biosciences--

SPRO Revenue FAQ


What is Spero Therapeutics’s yearly revenue?

Spero Therapeutics's yearly revenue for 2025 was $66.8M, representing an increase of 39.24% compared to 2024. The company's yearly revenue for 2024 was $47.98M, representing a decrease of -53.77% compared to 2023. SPRO's yearly revenue for 2023 was $103.78M, representing an increase of 113.63% compared to 2022.

What is Spero Therapeutics’s quarterly revenue?

Spero Therapeutics's quarterly revenue for Q1 2026 was $258K, a -99.35% decrease from the previous quarter (Q4 2025), and a -95.61% decrease year-over-year (Q1 2025). The company's quarterly revenue for Q4 2025 was $39.66M, a 1201.12% increase from the previous quarter (Q3 2025), and a 163.61% increase year-over-year (Q4 2024). SPRO's quarterly revenue for Q3 2025 was $3.05M, a -74.17% decrease from the previous quarter (Q2 2025), and a -77.37% decrease year-over-year (Q3 2024).

What is Spero Therapeutics’s revenue growth rate?

Spero Therapeutics's revenue growth rate for the last 3 years (2023-2025) was -35.63%, and for the last 5 years (2021-2025) was 2075.96%.

What are Spero Therapeutics’s revenue streams?

Spero Therapeutics's revenue streams in c 25 are Collaboration Revenue Related Party, Grant Revenue, and Collaboration Revenue. Collaboration Revenue Related Party generated $47.03M in revenue, accounting 70.41% of the company's total revenue, up 74.04% year-over-year. Grant Revenue generated $7.18M in revenue, accounting 10.75% of the company's total revenue, down -65.10% year-over-year. Collaboration Revenue generated $12.59M in revenue, accounting 18.84% of the company's total revenue, up 3292.45% year-over-year.

What is Spero Therapeutics’s main source of revenue?

For the fiscal year ending Dec 25, the largest source of revenue of Spero Therapeutics was Collaboration Revenue Related Party. This segment made a revenue of $47.03M, representing 70.41% of the company's total revenue.